Therapeutic Approaches to Target Cancer Stem Cells
نویسندگان
چکیده
منابع مشابه
Therapeutic Approaches to Target Cancer Stem Cells
The clinical relevance of cancer stem cells (CSC) remains a major challenge for current cancer therapies, but preliminary findings indicate that specific targeting may be possible. Recent studies have shown that these tumor subpopulations promote tumor angiogenesis through the increased production of VEGF, whereas the VEGF neutralizing antibody bevacizumab specifically inhibits CSC growth. More...
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Cancer stem cells (CSCs) are believed to be a principal cellular source for tumour progression and therapeutic drug resistance as they are capable of self-renewal and can differentiate into cancer cells. Importantly, CSCs acquire the ability to evade the killing effects of cytotoxic agents through changes at the genetic, epigenetic and micro-environment levels. Therefore, therapeutic strategies...
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Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radi...
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Introduction: Along with the use of stem cells technology, many jurisprudential, moral, and legal challenges have been created, including the exploitation of women, intentional abortion, conversion embryos into commodities, stem cells trade, breaking the human dignity, and threats caused by biological agents. Elimination of such possible consequences requires drafting laws and legal mechanisms ...
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ژورنال
عنوان ژورنال: Cancers
سال: 2011
ISSN: 2072-6694
DOI: 10.3390/cancers3033331